Male and female atria exhibit distinct acute electrophysiological responses to sex steroids

SP Wells; C O'Shea; S Hayes; KL Weeks; P Kirchhof; LMD Delbridge; D Pavlovic; JR Bell

Journal article

Male and female atria exhibit distinct acute electrophysiological responses to sex steroids

SP Wells, C O'Shea, S Hayes, KL Weeks, P Kirchhof, LMD Delbridge, D Pavlovic, JR Bell

Journal of Molecular and Cellular Cardiology Plus | ELSEVIER | Published : 2024

DOI: 10.1016/j.jmccpl.2024.100079

Abstract

The electrophysiological properties of the hearts of women and men are different. These differences are at least partly mediated by the actions of circulating estrogens and androgens on the cardiomyocytes. Experimentally, much of our understanding in this field is based on studies focusing on ventricular tissue, with considerably less known in the context of atrial electrophysiology. The aim of this investigation was to compare the electrophysiological properties of male and female atria and assess responses to acute sex steroid exposure. Age-matched adult male and female C57BL/6 mice were anesthetized (4 % isoflurane) and left atria isolated. Atria were loaded with Di-4-ANEPPS voltage sensi..

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University of Melbourne Researchers

Kate Weeks Author

Lea Delbridge Author

James Bell Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

This research was supported by the National Health and Medical Research Council (#1099352 and #1125453; L. M. D. Delbridge, J. R. Bell), the Australian Research Council (#DP160102404; L. M. D. Del-bridge) and the British Heart Foundation (PG/17/55/33087; RG/17/15/33106; FS/19/12/34204; FS/19/16/34169; FS/PhD/22/29309; D. Pavlovic). C. O'Shea is supported by a Sir Henry Wellcome Fellowship, Wellcome Trust, 221650/Z/20/Z. K.L. Weeks is supported by a Future Leader Fellowship from the National Heart Foundation of Australia (102539).